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Thursday, November 20, 2008

How to Grow New Eyes

Stem cells from frog eggs can be genetically prodded to develop into functional eyes in tadpoles, according to research presented at the Society of Neurosciences conference in Washington, DC. Michael Zuber and his colleagues from SUNY Upstate Medical University, in Syracuse, NY, genetically engineered the stem cells to express a set of transcription factors (proteins that trigger expression of other genes) that are known to regulate eye development. When transplanted onto frog embryos that had had one eye removed, the cells developed into all seven types of cells found in the retina and also grew connections to the appropriate target in the brain. Swim tests showed that the new eyes functioned properly: tadpoles stayed in the part of their tank with a white background, which is normal tadpole behavior, rather than a black background.

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